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H. Schmandke, Bergholz-Rehbrücke
Sesame seed , triticale (up to 19 mg/g) and soybean (up to 15 mg/g) have maximum concentrations of phytic acid. Processing may result in even higher levels, e.g. in sesame seed meal (up to 52 mg/g), faba bean protein isolate (up to 26 mg/g), wheat bran (up to 36 mg/g) and wheat gluten (up to 21 mg/g). Absorption of [3H]phytic acid is fast (94 % during 48 hours).
24 h after intragastric administration, 6.9 % are found in the gastrointestinal tract contents and 14.1 % in the feces of rats. At the same time 2.4 %, most of it as inositol and small amounts of inositol monophosphate, are excreted with the urine. These two degradation products are only detected in the plasma as well. The data suggest that phytic acid, after dephosphorylation in the mucosal cells of the small intestine, is distributed to the organs as inositol and its monophosphate. New studies in diabetic mice have shown that a dietary supplementation of up to 1.5 % phytic acid for 8 weeks decreases bloodglucose, total serum- cholesterol and LDL-cholesterol levels, but increases HDL cholesterol. The mechanism of this effect is largely unclear.
Keywords: dietary fibre, insulin resistance, leguminoses, myo-inositol, saponins.
Sie finden den Artikel in deutscher Sprache in Ernährungs Umschau 05/07 ab Seite 254.
H. Schmandke, Bergholz-Rehbrücke
Sesame seed , triticale (up to 19 mg/g) and soybean (up to 15 mg/g) have maximum concentrations of phytic acid. Processing may result in even higher levels, e.g. in sesame seed meal (up to 52 mg/g), faba bean protein isolate (up to 26 mg/g), wheat bran (up to 36 mg/g) and wheat gluten (up to 21 mg/g). Absorption of [3H]phytic acid is fast (94 % during 48 hours).
24 h after intragastric administration, 6.9 % are found in the gastrointestinal tract contents and 14.1 % in the feces of rats. At the same time 2.4 %, most of it as inositol and small amounts of inositol monophosphate, are excreted with the urine. These two degradation products are only detected in the plasma as well. The data suggest that phytic acid, after dephosphorylation in the mucosal cells of the small intestine, is distributed to the organs as inositol and its monophosphate. New studies in diabetic mice have shown that a dietary supplementation of up to 1.5 % phytic acid for 8 weeks decreases bloodglucose, total serum- cholesterol and LDL-cholesterol levels, but increases HDL cholesterol. The mechanism of this effect is largely unclear.
Keywords: dietary fibre, insulin resistance, leguminoses, myo-inositol, saponins.
Sie finden den Artikel in deutscher Sprache in Ernährungs Umschau 05/07 ab Seite 254.
Dietary phytic acid lowers blood-glucose and serum-lipid levels
H. Schmandke, Bergholz-Rehbrücke
Sesame seed , triticale (up to 19 mg/g) and soybean (up to 15 mg/g) have maximum concentrations of phytic acid. Processing may result in even higher levels, e.g. in sesame seed meal (up to 52 mg/g), faba bean protein isolate (up to 26 mg/g), wheat bran (up to 36 mg/g) and wheat gluten (up to 21 mg/g). Absorption of [3H]phytic acid is fast (94 % during 48 hours).
24 h after intragastric administration, 6.9 % are found in the gastrointestinal tract contents and 14.1 % in the feces of rats. At the same time 2.4 %, most of it as inositol and small amounts of inositol monophosphate, are excreted with the urine. These two degradation products are only detected in the plasma as well. The data suggest that phytic acid, after dephosphorylation in the mucosal cells of the small intestine, is distributed to the organs as inositol and its monophosphate. New studies in diabetic mice have shown that a dietary supplementation of up to 1.5 % phytic acid for 8 weeks decreases bloodglucose, total serum- cholesterol and LDL-cholesterol levels, but increases HDL cholesterol. The mechanism of this effect is largely unclear.
Keywords: dietary fibre, insulin resistance, leguminoses, myo-inositol, saponins.
Sie finden den Artikel in deutscher Sprache in Ernährungs Umschau 05/07 ab Seite 254.