Literatur:

1. Brown RK, Kelly FJ: Role of free radicals in the pathogenesis of cystic fibrosis. Thorax 1994; 49:738-742.

2. Dominguez C, Gartner S, Linan S, Cobos N, Moreno A: Enhanced oxidative damage in cystic fibrosis patients. Biofactors 1998; 8:149-53.

3. Montuschi P, Kharitonov SA, Ciabattoni G, Corradi M, van Rensen L, Geddes DM, Hodson ME, Barnes PJ: Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax 2000; 55:205-209.

4. Belloni PN, Garvin L, Mao CP, Bailey-Healy I, Leaffer D: Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000; 117:235S-241S.

5. Biesalski HK: Bedeutung von Vitamin A für die Lungenentwicklung. Monatsschr Kinderheilkd 2001; 149:S25-S32.

6. Biesalski HK, Grimm P: Taschenatlas der Ernährung. Georg Thieme Verlag, Stuttgart 1999; 140-141.

7. Winklhofer-Roob BM, Puhl H, Khoschsorur G, Van`t Hof MA, Esterbauer H, Shmerling DH: Enhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during beta-carotene supplementation in cystic fibrosis. Free Radic Biol Med 1995; 18:849-859.

8. van der Vliet A, Eiserich JP, Marelich GP, Halliwell B, Cross CE: Oxidative stress in cystic fibrosis: does it occur and does it matter? Adv Pharmacol 1997; 38:491-513.

9. Winklhofer-Roob BM, Ziouzenkova O, Puhl H, et al.: Impaired resistance to oxidation of low density lipoprotein in cystic fibrosis: Improvement during vitamin E supplementation. Free Radic Biol Med 1995; 19:725-733.

10. Benabdeslam H, Abidi H, Garcia I, Bellon G, Gilly R, Revol A: Lipid peroxidation and antioxidant defenses in cystic fibrosis patients. Clin Chem Lab Med 1999; 37:511-516.

11. Collins CE, Quaggiotto P, Wood L, O´Loughlin EV, Henry RL, Garg ML: Elevated plasma levels of F2 alpha isoprostane in cystic fibrosis. Lipids 1999; 34:551-556.

12. Sokol RJ, Reardon MC, Accurso FJ, et al.: Fat-soluble-vitamin status during the first year of life in infants with cystic fibrosis identified by screening of newborns. Am J Clin Nutr 1989; 50:1064-1071.

13. Nasr SZ, O´Leary MH, Hillermeier C: Correction of vitamin E deficiency with fat-soluble versus water-miscible preparations of vitamin E in patients with cystic fibrosis. J Pediatr 1993; 122:810-812.

14. Homnick DN, Cox JH, DeLoof MJ, Ringer TV: Carotenoid levels in normal children and in children with cystic fibrosis. J Pediatr 1993; 122:703-707.

15. Benabdeslam H, Garcia I, Bellon G, Gilly R, Revol A: Biochemical assessment of the nutritional status of cystic fibrosis patient treated with pancreatic enzyme extracts. Am J Clin Nutr 1998; 67:912-918.

16. Sinaasappel M, Stern M, Littlewood J, Wolfe S, Steinkamp G, Heijerman H, Robberecht E, Döring G for the Consensus Committee: Nutrition in patients with cystic fibrosis. A European consensus. JCF1 2002

17. Winklhofer-Roob BM, Van´t Hof MA, Shmerling D: Response to oral b -carotene supplementation in patients with cystic fibrosis: A 16-month follow-up study. Acta Paediatr 1995; 84:1132-1136.

18. Winklhofer-Roob BM, Ellemunter H, Frühwirth M, et al.: Plasma vitamin C concentrations in patients with cystic fibrosis: evidence of associations with lung inflammation. Am J Clin Nutr 1997; 65:1858-1866.

19. James DR, Owen G, Campbell IA, Goodchild MC: Vitamin A absorption in cystic fibrosis: Risk of hypervitaminosis A. Gut 1992; 33:707-710.

20. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL: Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Eur J Pediatr 1997; 156:949-951.

21. Duggan Ch, Colin AA, Agil A, Higgins L, Rifai N: Vitamin A status in acute exacerbations of cystic fibrosis. Am J Clin Nutr 1996; 64:635-639.

22. Biesalski HK: Nutritargeting. In: Biesalski HK, Köhrle J, Schürmann K (Hrsg.): Vitamine, Spurenelemente und Mineralstoffe – Prävention und Therapie mit Mikronährstoffen. Thieme Verlag, Stuttgart 2002; 724-727.

23. Jenning V, Gohla SH: Encapsulation of retinoids in solid lipid nanoparticles (SLNâ ). J Microencapsulation 2001; 18:149-158.

24. Biesalski HK, Reifen R, Fürst P, Edris M: Retinyl palmitate supplementation by inhalation of an aerosol improves vitamin A status of preschool children in Gondar (Ethiopia). Br J Nutr 1999; 82:179-182.

25. Biesalski HK: Vitamine. In: Biesalski HK, Fürst P, Kasper H, Kluthe R, Pölert W, Puchstein C, Stähelin HB (Hrsg.): Ernährungsmedizin. Georg Thieme Verlag, Stuttgart 1999; 111-158.





Literatur:

1. Brown RK, Kelly FJ: Role of free radicals in the pathogenesis of cystic fibrosis. Thorax 1994; 49:738-742.

2. Dominguez C, Gartner S, Linan S, Cobos N, Moreno A: Enhanced oxidative damage in cystic fibrosis patients. Biofactors 1998; 8:149-53.

3. Montuschi P, Kharitonov SA, Ciabattoni G, Corradi M, van Rensen L, Geddes DM, Hodson ME, Barnes PJ: Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax 2000; 55:205-209.

4. Belloni PN, Garvin L, Mao CP, Bailey-Healy I, Leaffer D: Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000; 117:235S-241S.

5. Biesalski HK: Bedeutung von Vitamin A für die Lungenentwicklung. Monatsschr Kinderheilkd 2001; 149:S25-S32.

6. Biesalski HK, Grimm P: Taschenatlas der Ernährung. Georg Thieme Verlag, Stuttgart 1999; 140-141.

7. Winklhofer-Roob BM, Puhl H, Khoschsorur G, Van`t Hof MA, Esterbauer H, Shmerling DH: Enhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during beta-carotene supplementation in cystic fibrosis. Free Radic Biol Med 1995; 18:849-859.

8. van der Vliet A, Eiserich JP, Marelich GP, Halliwell B, Cross CE: Oxidative stress in cystic fibrosis: does it occur and does it matter? Adv Pharmacol 1997; 38:491-513.

9. Winklhofer-Roob BM, Ziouzenkova O, Puhl H, et al.: Impaired resistance to oxidation of low density lipoprotein in cystic fibrosis: Improvement during vitamin E supplementation. Free Radic Biol Med 1995; 19:725-733.

10. Benabdeslam H, Abidi H, Garcia I, Bellon G, Gilly R, Revol A: Lipid peroxidation and antioxidant defenses in cystic fibrosis patients. Clin Chem Lab Med 1999; 37:511-516.

11. Collins CE, Quaggiotto P, Wood L, O´Loughlin EV, Henry RL, Garg ML: Elevated plasma levels of F2 alpha isoprostane in cystic fibrosis. Lipids 1999; 34:551-556.

12. Sokol RJ, Reardon MC, Accurso FJ, et al.: Fat-soluble-vitamin status during the first year of life in infants with cystic fibrosis identified by screening of newborns. Am J Clin Nutr 1989; 50:1064-1071.

13. Nasr SZ, O´Leary MH, Hillermeier C: Correction of vitamin E deficiency with fat-soluble versus water-miscible preparations of vitamin E in patients with cystic fibrosis. J Pediatr 1993; 122:810-812.

14. Homnick DN, Cox JH, DeLoof MJ, Ringer TV: Carotenoid levels in normal children and in children with cystic fibrosis. J Pediatr 1993; 122:703-707.

15. Benabdeslam H, Garcia I, Bellon G, Gilly R, Revol A: Biochemical assessment of the nutritional status of cystic fibrosis patient treated with pancreatic enzyme extracts. Am J Clin Nutr 1998; 67:912-918.

16. Sinaasappel M, Stern M, Littlewood J, Wolfe S, Steinkamp G, Heijerman H, Robberecht E, Döring G for the Consensus Committee: Nutrition in patients with cystic fibrosis. A European consensus. JCF1 2002

17. Winklhofer-Roob BM, Van´t Hof MA, Shmerling D: Response to oral b -carotene supplementation in patients with cystic fibrosis: A 16-month follow-up study. Acta Paediatr 1995; 84:1132-1136.

18. Winklhofer-Roob BM, Ellemunter H, Frühwirth M, et al.: Plasma vitamin C concentrations in patients with cystic fibrosis: evidence of associations with lung inflammation. Am J Clin Nutr 1997; 65:1858-1866.

19. James DR, Owen G, Campbell IA, Goodchild MC: Vitamin A absorption in cystic fibrosis: Risk of hypervitaminosis A. Gut 1992; 33:707-710.

20. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL: Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Eur J Pediatr 1997; 156:949-951.

21. Duggan Ch, Colin AA, Agil A, Higgins L, Rifai N: Vitamin A status in acute exacerbations of cystic fibrosis. Am J Clin Nutr 1996; 64:635-639.

22. Biesalski HK: Nutritargeting. In: Biesalski HK, Köhrle J, Schürmann K (Hrsg.): Vitamine, Spurenelemente und Mineralstoffe – Prävention und Therapie mit Mikronährstoffen. Thieme Verlag, Stuttgart 2002; 724-727.

23. Jenning V, Gohla SH: Encapsulation of retinoids in solid lipid nanoparticles (SLNâ ). J Microencapsulation 2001; 18:149-158.

24. Biesalski HK, Reifen R, Fürst P, Edris M: Retinyl palmitate supplementation by inhalation of an aerosol improves vitamin A status of preschool children in Gondar (Ethiopia). Br J Nutr 1999; 82:179-182.

25. Biesalski HK: Vitamine. In: Biesalski HK, Fürst P, Kasper H, Kluthe R, Pölert W, Puchstein C, Stähelin HB (Hrsg.): Ernährungsmedizin. Georg Thieme Verlag, Stuttgart 1999; 111-158.



(EU 10/2002, S. 386 ff.) Back, E., Stern, M., Biesalski, H.K.: Bedeutung antioxidativer Systeme und des Vitamin A bei cystischer Fibrose

Literatur:

1. Brown RK, Kelly FJ: Role of free radicals in the pathogenesis of cystic fibrosis. Thorax 1994; 49:738-742.

2. Dominguez C, Gartner S, Linan S, Cobos N, Moreno A: Enhanced oxidative damage in cystic fibrosis patients. Biofactors 1998; 8:149-53.

3. Montuschi P, Kharitonov SA, Ciabattoni G, Corradi M, van Rensen L, Geddes DM, Hodson ME, Barnes PJ: Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax 2000; 55:205-209.

4. Belloni PN, Garvin L, Mao CP, Bailey-Healy I, Leaffer D: Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000; 117:235S-241S.

5. Biesalski HK: Bedeutung von Vitamin A für die Lungenentwicklung. Monatsschr Kinderheilkd 2001; 149:S25-S32.

6. Biesalski HK, Grimm P: Taschenatlas der Ernährung. Georg Thieme Verlag, Stuttgart 1999; 140-141.

7. Winklhofer-Roob BM, Puhl H, Khoschsorur G, Van`t Hof MA, Esterbauer H, Shmerling DH: Enhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during beta-carotene supplementation in cystic fibrosis. Free Radic Biol Med 1995; 18:849-859.

8. van der Vliet A, Eiserich JP, Marelich GP, Halliwell B, Cross CE: Oxidative stress in cystic fibrosis: does it occur and does it matter? Adv Pharmacol 1997; 38:491-513.

9. Winklhofer-Roob BM, Ziouzenkova O, Puhl H, et al.: Impaired resistance to oxidation of low density lipoprotein in cystic fibrosis: Improvement during vitamin E supplementation. Free Radic Biol Med 1995; 19:725-733.

10. Benabdeslam H, Abidi H, Garcia I, Bellon G, Gilly R, Revol A: Lipid peroxidation and antioxidant defenses in cystic fibrosis patients. Clin Chem Lab Med 1999; 37:511-516.

11. Collins CE, Quaggiotto P, Wood L, O´Loughlin EV, Henry RL, Garg ML: Elevated plasma levels of F2 alpha isoprostane in cystic fibrosis. Lipids 1999; 34:551-556.

12. Sokol RJ, Reardon MC, Accurso FJ, et al.: Fat-soluble-vitamin status during the first year of life in infants with cystic fibrosis identified by screening of newborns. Am J Clin Nutr 1989; 50:1064-1071.

13. Nasr SZ, O´Leary MH, Hillermeier C: Correction of vitamin E deficiency with fat-soluble versus water-miscible preparations of vitamin E in patients with cystic fibrosis. J Pediatr 1993; 122:810-812.

14. Homnick DN, Cox JH, DeLoof MJ, Ringer TV: Carotenoid levels in normal children and in children with cystic fibrosis. J Pediatr 1993; 122:703-707.

15. Benabdeslam H, Garcia I, Bellon G, Gilly R, Revol A: Biochemical assessment of the nutritional status of cystic fibrosis patient treated with pancreatic enzyme extracts. Am J Clin Nutr 1998; 67:912-918.

16. Sinaasappel M, Stern M, Littlewood J, Wolfe S, Steinkamp G, Heijerman H, Robberecht E, Döring G for the Consensus Committee: Nutrition in patients with cystic fibrosis. A European consensus. JCF1 2002

17. Winklhofer-Roob BM, Van´t Hof MA, Shmerling D: Response to oral b -carotene supplementation in patients with cystic fibrosis: A 16-month follow-up study. Acta Paediatr 1995; 84:1132-1136.

18. Winklhofer-Roob BM, Ellemunter H, Frühwirth M, et al.: Plasma vitamin C concentrations in patients with cystic fibrosis: evidence of associations with lung inflammation. Am J Clin Nutr 1997; 65:1858-1866.

19. James DR, Owen G, Campbell IA, Goodchild MC: Vitamin A absorption in cystic fibrosis: Risk of hypervitaminosis A. Gut 1992; 33:707-710.

20. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL: Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Eur J Pediatr 1997; 156:949-951.

21. Duggan Ch, Colin AA, Agil A, Higgins L, Rifai N: Vitamin A status in acute exacerbations of cystic fibrosis. Am J Clin Nutr 1996; 64:635-639.

22. Biesalski HK: Nutritargeting. In: Biesalski HK, Köhrle J, Schürmann K (Hrsg.): Vitamine, Spurenelemente und Mineralstoffe – Prävention und Therapie mit Mikronährstoffen. Thieme Verlag, Stuttgart 2002; 724-727.

23. Jenning V, Gohla SH: Encapsulation of retinoids in solid lipid nanoparticles (SLNâ ). J Microencapsulation 2001; 18:149-158.

24. Biesalski HK, Reifen R, Fürst P, Edris M: Retinyl palmitate supplementation by inhalation of an aerosol improves vitamin A status of preschool children in Gondar (Ethiopia). Br J Nutr 1999; 82:179-182.

25. Biesalski HK: Vitamine. In: Biesalski HK, Fürst P, Kasper H, Kluthe R, Pölert W, Puchstein C, Stähelin HB (Hrsg.): Ernährungsmedizin. Georg Thieme Verlag, Stuttgart 1999; 111-158.

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Veröffentlicht: 04.10.2002

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